Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA. Massachusetts General Hospital Biostatistics Center, Boston, MA, USA. Division of Pulmonology, Boston Children's Hospital, Boston, MA, USA. Division of Pulmonology and Critical Care, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Division of Pulmonology and Critical Care, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, MA, USA.